Details

Autor(en) / Beteiligte

• Yoshida, Hisato
• Hoshino, Hitomi
• Imamura, Yoshiaki
• Yoshimura, Hitoshi
• Sano, Kazuo
• Kobayashi, Motohiro

Titel

Role of sialyl 6‐sulfo Lewis X in antitumor immunity against oral squamous cell carcinoma

Ist Teil von

• Journal of oral pathology & medicine, 2017-10, Vol.46 (9), p.759-765

Ort / Verlag

Denmark: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Background Tumor‐infiltrating lymphocytes (TILs) reportedly play a pivotal role in antitumor immunity against oral squamous cell carcinoma (OSCC); however, mechanisms governing TIL recruitment to OSCC tissues remain to be clarified. This study was undertaken to assess a potential association between TILs and high endothelial venule (HEV)‐like vessels that express sialyl 6‐sulfo Lewis X (LeX). Methods OSCC tissue sections (n=41) were subjected to immunohistochemistry for sialyl 6‐sulfo LeX and CD34 to allow quantitation of HEV‐like vessels. Triple immunohistochemistry for sialyl 6‐sulfo LeX and either CD3 and CD20 or CD4 and CD8 was conducted to determine which lymphocyte subset is more closely associated with HEV‐like vessels. Results HEV‐like vessels expressing sialyl 6‐sulfo LeX were detected in 27 of 41 (65.9%) OSCC cases, and these vessels were more frequently found in early disease (T1/T2 stages) compared with advanced (T3/T4) stages. The number of T cells attached to the inner surface of these HEV‐like vessels was significantly greater than that of B cells, while the number of CD4+ helper T cells and CD8+ cytotoxic T cells did not differ significantly. Interestingly, sialyl 6‐sulfo LeX was also expressed on the membrane of a fraction of OSCC cells, and CD8+ cytotoxic T cells were almost exclusively found attached to these carcinoma cells. Conclusions Sialyl 6‐sulfo LeX is displayed not only on HEV‐like vessels but also on OSCC cells and may potentially function in antitumor immunity against OSCC.