Details

Autor(en) / Beteiligte

• Zheng, Kai-Lu
• You, Min-Qi
• Shu, Wen-Ming
• Wu, Yan-Dong
• Wu, An-Xin

Titel

Acid-Mediated Intermolecular [3 + 2] Cycloaddition toward Pyrrolo[2,1‑a]isoquinolines: Total Synthesis of the Lamellarin Core and Lamellarin G Trimethyl Ether

Ist Teil von

• Organic letters, 2017-05, Vol.19 (9), p.2262-2265

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A novel one-pot reaction has been developed for the efficient synthesis of pyrrolo­[2,1-a]­isoquinolines and 1-dearyllamellarin core from (E)-(2-nitrovinyl)­benzenes and azomethine ylides generated in situ. This strategy provides a concise total synthesis of the lamellarin core and lamellarin G trimethyl ether using electrophilic substitution and palladium-catalyzed Suzuki–Miyaura cross-coupling reactions.