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Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats
Neurourology and urodynamics, 2017-03, Vol.36 (3), p.604-609
Sugaya, Kimio
Nishijima, Saori
Kadekawa, Katsumi
Ashitomi, Katsuhiro
Ueda, Tomoyuki
Yamamoto, Hideyuki
Hattori, Tsuyoshi
2017
Details
Autor(en) / Beteiligte
Sugaya, Kimio
Nishijima, Saori
Kadekawa, Katsumi
Ashitomi, Katsuhiro
Ueda, Tomoyuki
Yamamoto, Hideyuki
Hattori, Tsuyoshi
Titel
Action of naftopidil on spinal serotonergic neurotransmission for inhibition of the micturition reflex in rats
Ist Teil von
Neurourology and urodynamics, 2017-03, Vol.36 (3), p.604-609
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Aims We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex. Methods We examined (1) urinary 5‐hydroxyindole acetic acid (5‐HIAA) after intraperitoneal administration of saline, para‐chlorophenylalanine (PCPA; a serotonin synthetic enzyme inhibitor), and/or 5‐hydroxytryptophan (5‐HTP; a serotonin precursor); (2) isovolumetric cystometry after intraperitoneal administration of saline, PCPA, and/or 5‐HTP and intravenous injection of naftopidil; and (3) isovolumetric cystometry before and after intrathecal administration of serotonin (5‐HT) receptor antagonists and intravenous injection of naftopidil. Results PCPA decreased and 5‐HTP increased urinary 5‐HIAA/creatinine. Intraperitoneal injection of PCPA did not influence cystometric parameters. Intraperitoneal injection of 5‐HTP significantly shortened the interval between bladder contractions. Intravenous injection of naftopidil transiently abolished bladder contractions. However, the duration of abolishment of bladder contractions after injection of naftopidil in rats given PCPA was significantly shorter than that in rats given vehicle, but significantly longer than that in rats given PCPA and 5‐HTP. Intrathecal injection of 5‐HT1B, 5‐HT3, or 5‐HT7 receptor antagonists significantly prolonged the interval between bladder contractions. Intrathecal injection of 5‐HT1D or 5‐HT2B receptor antagonists significantly shortened the interval between bladder contractions. Combined administration of the maximum non‐effective dose of 5‐HT1D, 5‐HT2A, 5‐HT2B, 5‐HT2C, or 5‐HT3 receptor antagonists and intravenous injection of naftopidil significantly shortened the duration of abolishment of bladder contraction compared to intravenous injection of naftopidil alone. Conclusions Naftopidil may inhibit the micturition reflex via 5‐HT1D, 5‐HT2A, 5‐HT2B, 5‐HT2C, and 5‐HT3 receptors in the spinal cord. Neurourol. Urodynam. 36:604–609, 2017. © 2016 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0733-2467
eISSN: 1520-6777
DOI: 10.1002/nau.23028
Titel-ID: cdi_proquest_miscellaneous_1888979631
Format
–
Schlagworte
5-Hydroxytryptophan - pharmacology
,
5‐HT
,
Acetic acid
,
Adrenergic alpha-Antagonists - pharmacology
,
Animals
,
Bladder
,
Contraction
,
Creatinine
,
Female
,
Fenclonine - pharmacology
,
Hydroxyindoleacetic Acid - urine
,
Injection
,
Intravenous administration
,
naftopidil
,
Naphthalenes - pharmacology
,
Neurotransmission
,
Piperazines - pharmacology
,
Rats
,
Rats, Sprague-Dawley
,
Reflex - drug effects
,
Reflexes
,
Rodents
,
Serotonin
,
Serotonin - metabolism
,
Serotonin Antagonists - pharmacology
,
Serotonin receptors
,
Serotonin S1 receptors
,
Serotonin S2 receptors
,
Serotonin S3 receptors
,
Serotonin S7 receptors
,
Spinal cord
,
Spinal Cord - drug effects
,
Spinal Cord - metabolism
,
Synaptic Transmission - drug effects
,
Urinary bladder
,
Urination
,
Urination - drug effects
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