Vaccine, 2017-04, Vol.35 (15), p.1964-1971
2017
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- Autor(en) / Beteiligte
- Titel
- A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response
- Ist Teil von
- Vaccine, 2017-04, Vol.35 (15), p.1964-1971
- Ort / Verlag
- Netherlands: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • KIN1148 induces dose-dependent expression of IRF3-responsive promoters. • KIN1148 provides a dose-sparing effect with a H1N1 influenza split vaccine. • Immunization with KIN1148 and vaccine promotes a Th2-biased response post challenge. • Prime-boost immunization induces functional antibodies that control viral infection. • A balanced immune response may help to control immunopathology.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0264-410X, 1873-2518eISSN: 1873-2518DOI: 10.1016/j.vaccine.2017.01.053Titel-ID: cdi_proquest_miscellaneous_1888978780
- Format
- –
- Schlagworte
- Adjuvant, Adjuvants, Adjuvants, Immunologic - administration & dosage, Adjuvants, Immunologic - isolation & purification, Allergy and Immunology, Animals, Antiinfectives and antibacterials, Antiviral drugs, Benzothiazoles - administration & dosage, Benzothiazoles - isolation & purification, Binding sites, Cell Line, Cytokines, DEAD Box Protein 58 - metabolism, Disease Models, Animal, Drug Evaluation, Preclinical, Experiments, Female, Gene expression, Hemagglutinins, High-Throughput Screening Assays, Humans, Immune response, Immunization, Infections, Influenza, Influenza A virus, Influenza Vaccines - administration & dosage, Influenza Vaccines - immunology, Interferon Regulatory Factor-3 - metabolism, IRF3, Ligands, Lymph nodes, Mice, Inbred C57BL, Nucleic acids, Orthomyxoviridae, Orthomyxoviridae Infections - prevention & control, Pandemics, Pattern recognition, Receptors, Immunologic, Survival Analysis, Swine flu, Translocation, Vaccination, Vaccine, Vaccines, Viruses