Details

Autor(en) / Beteiligte

• Liu, Jiaqi
• Liu, Meiqing
• Chen, Linxi

Titel

Novel pathogenesis： regulation of apoptosis by Apelin/APJ system

Ist Teil von

• Acta biochimica et biophysica Sinica, 2017-06, Vol.49 (6), p.471-478

Ort / Verlag

China

Erscheinungsjahr

2017

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Apelin is the endogenous peptide APJ receptor, while APJ is a member of the G protein-coupled receptors family. Recent evidence strongly suggests that Apelin/APJ system influences apoptosis in various diseases through different signal pathways. In this review, we discuss the possible mechan- isms by which the Apelin/APJ system inhibits apoptosis, including the phosphatidylinositol-3-kinase （PI3K）/Akt, ERK1/2, caspase signaling, and autophagy pathway. We also summarize the role of Apelin/APJ system in apoptosis in myocardial ischemia-reperfusion （I/R） injury, pulmonary artery hypertension, retinal neovascular disease, acute renal injury, skeletal homeostasis, and gastrointes- tinal diseases. Apelin/APJ system decreases myocardial infarction size and alleviates myocardial I/R injury by inhibiting cardiomyocytes apoptosis. However, Apelin/APJ system improves pulmonary artery hypertension via increasing apoptosis. Apelin/APJ system exerts neuroprotective effect by blocking apoptosis and participates in the recovery of retinal neovascular disease by suppressing apoptosis. Apelin/APJ system also shows anti-apoptotic effect against acute renal injury and plays a role in regulating skeletal homeostasis. In gastrointestinal disease, Apelin/APJ system plays a poten- tial physiological role in gastrointestinal cytoprotection by regulating apoptosis. We hope that a bet- ter understanding of the Apelin/APJ system will help to discover new disease pathogenesis and find possible therapeutic targets of the Apelin/APJ system essential for various diseases.