Details

Autor(en) / Beteiligte

• Phan, Tri Giang
• Tangye, Stuart G

Titel

Memory B cells: total recall

Ist Teil von

• Current opinion in immunology, 2017-04, Vol.45, p.132-140

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • Multiple subsets of memory B cells exist, with distinct functions and developmental requirements. • Human IgM+ CD27+ memory B cells require innate signalling to form but germinal centres for re-modelling. • Class-switched memory B cells require CD4+ T cell help and GC for their generation and maintenance. • Memory B cells localise to distinct anatomical sites, according to isotype and site of activation. • Memory B cell generation is controlled by transcriptional networks.