Details

Autor(en) / Beteiligte

• Bellavia, Andrea
• Williams, Paige L
• DiMeglio, Linda A
• Hazra, Rohan
• Abzug, Mark J
• Patel, Kunjal
• Jacobson, Denise L
• Van Dyke, Russell B
• Geffner, Mitchell E

Titel

Delay in sexual maturation in perinatally HIV-infected youths is mediated by poor growth

Ist Teil von

• AIDS (London), 2017-06, Vol.31 (9), p.1333-1341

Ort / Verlag

England: Copyright Wolters Kluwer Health, Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• OBJECTIVE:To evaluate the association between HIV infection and sexual maturation, and mediation of this association by HIV effects on growth. DESIGN:Pooled data were analyzed from two longitudinal cohort studies, the International Maternal Pediatric Adolescent AIDS Clinical Trials P219/219C Study (1993–2007) and the Pediatric HIV/AIDS Cohort Study Adolescent Master Protocol (2007–2015), including perinatally HIV-infected (PHIV) and HIV-exposed uninfected (PHEU) youths. METHODS:We evaluated age at sexual maturity among 2539 PHIV and PHEU adolescents based on annual physician-assessed pubertal staging measures. Interval-censored regression models were used to evaluate associations of HIV infection with age at maturity. Mediation analyses accounting for height and BMI Z-scores at specific ages were used to estimate direct and indirect effects of HIV infection on age at sexual maturity. RESULTS:Mean ages at sexual maturity for PHIV girls (n = 1032) were 15.5 years for both female breast and pubic hair and 15.9 and 15.8 years for PHIV boys (n = 1054) for genitalia and pubic hair, respectively. PHIV youths matured approximately 6 months later on average than PHEU (n = 221 girls and 232 boys), and this difference persisted after adjustment for race/ethnicity and birth cohort. BMI and height Z-scores mediated the association between HIV infection and later maturation in girls, accounting for up to 74% of the total HIV effect. Only height Z-scores mediated the effect of HIV on male age at maturity, accounting for up to 98% of the HIV effect. CONCLUSION:PHIV youths attain sexual maturity later on average than PHEU youths. Much of this difference may be attributable to deficient growth, suggesting directions for future interventions.