Details

Autor(en) / Beteiligte

• Dibek Misirlioglu, Emine, MD
• Guvenir, Hakan, MD
• Bahceci, Semiha, MD
• Haktanir Abul, Mehtap, MD
• Can, Demet, MD
• Usta Guc, Belgin Emine, MD
• Erkocoğlu, Mustafa, MD
• Toyran, Muge, MD
• Nacaroglu, Hikmet Tekin, MD
• Civelek, Ersoy, MD
• Buyuktiryaki, Betul, MD
• Ginis, Tayfur, MD
• Orhan, Fazil, MD
• Kocabas, Can Naci, MD

Titel

Severe Cutaneous Adverse Drug Reactions in Pediatric Patients: A Multicenter Study

Ist Teil von

• The journal of allergy and clinical immunology in practice (Cambridge, MA), 2017-05, Vol.5 (3), p.757-763

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The severe cutaneous adverse drug reactions (SCARs) are rare but could be life-threatening. These include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN), and acute generalized exanthematous pustulosis. Objective The purpose of this study was the evaluation of the clinical characteristics of patients with the diagnosis of SCARs. Methods Patients who were diagnosed with SCARs between January 2011 and May 2016 by pediatric allergy clinics in the provinces of Ankara, Trabzon, Izmir, Adana, and Bolu were included in this multicenter study. Clinical and laboratory findings, the time between suspected drug intake and development of clinical findings, treatments they have received, and length of recovery time were recorded. Results Fifty-eight patients with SCARs were included in this study. The median age of the patients was 8.2 years (interquartile range, 5.25-13 years) and 50% (n = 29) were males. Diagnosis was Stevens-Johnson syndrome/TEN in 60.4% (n = 35), DRESS in 27.6% (n = 16), and acute generalized exanthematous pustulosis in 12% (n = 7) of the patients. In 93.1% of the patients, drugs were the cause of the reactions. Antibiotics ranked first among the drugs (51.7%) and antiepileptic drugs were the second (31%) most common. A patient who was diagnosed with TEN developed lagophthalmos and a patient who was diagnosed with DRESS developed secondary diabetes mellitus. Only 1 patient with the diagnosis of TEN died. Conclusions SCARs in children are not common but potentially serious. Early diagnosis and appropriate treatment of SCARs will reduce the incidence of morbidity and mortality.