Details

Autor(en) / Beteiligte

• Drost, Jarno
• Clevers, Hans

Titel

Translational applications of adult stem cell-derived organoids

Ist Teil von

• Development (Cambridge), 2017-03, Vol.144 (6), p.968-975

Ort / Verlag

England: The Company of Biologists Ltd

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Adult stem cells from a variety of organs can be expanded long-term as three-dimensional organotypic structures termed organoids. These adult stem cell-derived organoids retain their organ identity and remain genetically stable over long periods of time. The ability to grow organoids from patient-derived healthy and diseased tissue allows for the study of organ development, tissue homeostasis and disease. In this Review, we discuss the generation of adult stem cell-derived organoid cultures and their applications in disease modeling, personalized cancer therapy and regenerative medicine.