Details

Autor(en) / Beteiligte

• Goullee, Hayley
• Wadley, Antonia L.
• Cherry, Catherine L.
• Allcock, Richard J. N.
• Black, Michael
• Kamerman, Peter R.
• Price, Patricia

Titel

Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients

Ist Teil von

• Journal of neurovirology, 2016-08, Vol.22 (4), p.508-517

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R , P2X4R and CAMKK2 . HIV-SN status was assessed using the Brief Peripheral Neuropathy Screening tool, with SN defined by bilateral symptoms and signs. Forty-five SNPs in P2X7R , P2X4R and CAMKK2 were genotyped using TaqMan fluorescent probes, in DNA samples from 153 HIV + black Southern African patients exposed to stavudine. Haplotypes were derived using the fastPHASE algorithm, and SNP genotypes and haplotypes associated with HIV-SN were identified. Optimal logistic regression models included demographics (age and height), with SNPs (model p  < 0.0001; R 2  = 0.19) or haplotypes (model p  < 0.0001; R 2  = 0.18, n  = 137 excluding patients carrying CAMKK2 haplotypes perfectly associated with SN). Overall, CAMKK2 exhibited the strongest associations with HIV-SN, with two SNPs and six haplotypes predicting SN status in black Southern Africans. This gene warrants further study.