Details

Autor(en) / Beteiligte

• Lorx, András
• Czövek, Dorottya
• Gingl, Zoltán
• Makan, Gergely
• Radics, Bence
• Bartusek, Dóra
• Szigeti, Szabolcs
• Gál, János
• Losonczy, György
• Sly, Peter D
• Hantos, Zoltán

Titel

Airway dynamics in COPD patients by within-breath impedance tracking: effects of continuous positive airway pressure

Ist Teil von

• The European respiratory journal, 2017-02, Vol.49 (2), p.1601270-1601270

Ort / Verlag

England: European Respiratory Society Journals Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Tracking of the within-breath changes of respiratory mechanics using the forced oscillation technique may provide outcomes that characterise the dynamic behaviour of the airways during normal breathing.We measured respiratory resistance ( ) and reactance ( ) at 8 Hz in 55 chronic obstructive pulmonary disease (COPD) patients and 20 healthy controls, and evaluated and as functions of gas flow ( ') and volume ( ) during normal breathing cycles. In 12 COPD patients, additional measurements were made at continuous positive airway pressure (CPAP) levels of 4, 8, 14 and 20 hPa.The and ' and relationships displayed a variety of loop patterns, allowing characterisation of physiological and pathological processes. The main outcomes emerging from the within-breath analysis were the loop area (AXV) quantifying expiratory flow limitation, and the tidal change in during inspiration (Δ ) reflecting alteration in lung inhomogeneity in COPD. With increasing CPAP, AXV and Δ approached the normal ranges, although with a large variability between individuals, whereas mean remained unchanged.Within-breath tracking of and allows an improved assessment of expiratory flow limitation and functional inhomogeneity in COPD; thereby it may help identify the physiological phenotypes of COPD and determine the optimal level of respiratory support.