Details

Autor(en) / Beteiligte

• Nottage, Michelle K.
• Lin, Charles
• Hughes, Brett G. M.
• Kenny, Lizbeth
• Smith, David D.
• Houston, Kathleen
• Francesconi, Alessandra

Titel

Prospective study of definitive chemoradiation in locally or regionally advanced squamous cell carcinoma of the skin

Ist Teil von

• Head & neck, 2017-04, Vol.39 (4), p.679-683

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• ABSTRACT Background The purpose of this study was to present our evaluation of the outcomes of concurrent chemoradiotherapy (CRT) in patients with locally advanced cutaneous squamous cell carcinoma (SCC). Methods This was a prospective phase II study. The primary endpoint was complete response (CR). Patients with locally/regionally advanced cutaneous SCC deemed unsuitable for surgery received definitive radiotherapy (RT; 70 Gy in 35fractions) and concurrent weekly platinum‐based chemotherapy (cisplatin 40 mg/m2 or carboplatin area under the curve 2). Results Twenty‐one patients were enrolled in this study. Eighteen patients had a locally advanced primary or nodal disease in the head and neck region with 66% having stage IV nonmetastatic disease. Of 19 evaluable patients, 10 achieved a CR to definitive CRT with 2 further patients rendered disease‐free by salvage surgery for an overall CR of 63%. Conclusion This is the only prospective series of CRT for cutaneous SCC. A high CR rate was documented in patients with locoregional advanced disease who were unable to undergo surgery. © 2016 Wiley Periodicals, Inc. Head Neck 39: 679–683, 2017