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Taylor & Francis Journals Auto-Holdings Collection
Beschreibungen/Notizen
To prepare and validate the efficacy of a novel targeted drug delivery system - octreotide (Oct)-modified oleanolic acid (OA) liposomes.
OA liposomes (OA-L) were prepared by an ethanol injection method. The Oct-modified OA liposomes (O-OA-L) were synthesized and their properties were evaluated. Cellular uptake and competition inhibition studies were performed.
The OA vesicles presented satisfactory particles size (100-200 nm), stability and drug release characteristics; their ζ potential was -1.42 ± 0.08 mV. The O-OA-L had a higher cell proliferation inhibitory activity and cellular uptake than that of OA-L for somatostatin receptor-positive A549 cells.
The O-OA-L, as a promising agent, can target actively the lesion site with safe and high-efficiency pattern.