Details

Autor(en) / Beteiligte

• Yu, Jianfei
• Duan, Meng
• Wu, Weilong
• Qi, Xiaotian
• Xue, Peng
• Lan, Yu
• Dong, Xiu‐Qin
• Zhang, Xumu

Titel

Readily Accessible and Highly Efficient Ferrocene‐Based Amino‐Phosphine‐Alcohol (f‐Amphol) Ligands for Iridium‐Catalyzed Asymmetric Hydrogenation of Simple Ketones

Ist Teil von

• Chemistry : a European journal, 2017-01, Vol.23 (4), p.970-975

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• We have successfully developed a series of novel and modular ferrorence‐based amino‐phosphine‐alcohol (f‐Amphol) ligands, and applied them to iridium‐catalyzed asymmetric hydrogenation of various simple ketones to afford the corresponding chiral alcohols with excellent enantioselectivities and conversions (98–99.9 % ee, >99 % conversion, turnover number up to 200 000). Control experiments and density functional theory (DFT) calculations have shown that the hydroxyl group of our f‐Amphol ligands played a key role in this asymmetric hydrogenation. Pure and simple: A series of novel and modular ferrorence‐based amino‐phosphine‐alcohol (f‐Amphol) ligands have been developed and applied to iridium‐catalyzed asymmetric hydrogenation of various simple ketones to afford the corresponding chiral alcohols with excellent enantioselectivities and conversions (see scheme). Control experiments and density functional calculations have shown that the hydroxyl group of the f‐Amphol ligands played a key role in this asymmetric hydrogenation.