Details

Autor(en) / Beteiligte

• Wright, Karen
• Quinodoz, Pierre
• Drouillat, Bruno
• Couty, François

Titel

A one carbon staple for orthogonal copper-catalyzed azide-alkyne cycloadditions

Ist Teil von

• Chemical communications (Cambridge, England), 2017, Vol.53 (2), p.321-323

Ort / Verlag

England

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We describe herein the use of α-hydroxy-β-azidotetrazoles, easily prepared in one step from α,β-epoxynitriles, as new scaffolds for orthogonal CuAAC reactions performed on the same carbon atom. After a first ligation involving an alkyne with the β-azido moiety, treatment with EDC smoothly releases an alkyne from the remaining α-hydroxytetrazole, ready for a second CuAAC reaction. This "double click" process can be performed iteratively, leading to triazolamers.