Details

Autor(en) / Beteiligte

• BOEKELHEIDE, Kim
• FLEMING, Shawna L
• THOMPSON, Stephanie
• ALLIO, Theresa
• EMBREE-KU, Michelle E
• HALL, Susan J
• JOHNSON, Kamin J
• EUN JI KWON
• PATEL, Sutchin R
• RASOULPOUR, Reza J
• SCHOENFELD, Heidi A

Titel

2,5-Hexanedione-induced testicular injury

Ist Teil von

• Annual review of pharmacology and toxicology, 2003-01, Vol.43 (1), p.125-147

Ort / Verlag

Palo Alto, CA: Annual Reviews

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.