Details

Autor(en) / Beteiligte

• Yue, Huifeng
• Guo, Lin
• Lee, Shao‐Chi
• Liu, Xiangqian
• Rueping, Magnus

Titel

Selective Reductive Removal of Ester and Amide Groups from Arenes and Heteroarenes through Nickel‐Catalyzed C−O and C−N Bond Activation

Ist Teil von

• Angewandte Chemie International Edition, 2017-03, Vol.56 (14), p.3972-3976

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An inexpensive nickel(II) catalyst and a hydrosilane were used for the efficient reductive defunctionalization of aryl and heteroaryl esters through a decarbonylative pathway. This versatile method could be used for the removal of ester and amide functional groups from various organic molecules. Moreover, a scale‐up experiment and a synthetic application based on the use of a removable carboxylic acid directing group highlight the usefulness of this reaction. Now you see it… now you don't: An inexpensive nickel(II) catalyst and a hydrosilane were used for the efficient reductive defunctionalization of aryl and heteroaryl esters by a decarbonylative pathway (see scheme). This versatile method is suitable for the removal of ester and amide functional groups, including carbonyl directing groups, from a variety of organic molecules.