Details

Autor(en) / Beteiligte

• Ngoc, Ninh Thi
• Hanh, Tran Thi Hong
• Thanh, Nguyen Van
• Thao, Do Thi
• Cuong, Nguyen Xuan
• Nam, Nguyen Hoai
• Thung, Do Cong
• Kiem, Phan Van
• Minh, Chau Van

Titel

Cytotoxic Steroids from the Vietnamese Soft Coral Sinularia leptoclados

Ist Teil von

• Chemical and Pharmaceutical Bulletin, 2017/06/01, Vol.65(6), pp.593-597

Ort / Verlag

Japan: The Pharmaceutical Society of Japan

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Fifteen steroids, including two new compounds, leptosteroid (1) and 5,6β-epoxygorgosterol (2), were isolated and structurally elucidated from the Vietnamese soft coral Sinularia leptoclados. Their cytotoxic effect against a panel of eight human cancer cell lines was evaluated using sulforhodamine B (SRB) method. Significant cytotoxicity against hepatoma cancer (HepG2, IC50=21.13±0.70 µM) and colon adenocarcinoma (SW480, IC50=28.65±1.53 µM) cell lines were observed for 1 and against acute leukemia (HL-60, IC50=20.53±2.26 µM) and SW480 (IC50=26.61±1.59 µM) for ergost-5-en-3β,7β-diol (8). In addition, 3β,7β-dihydroxyergosta-5,24(28)-diene (13) showed significant cytotoxic activity on all tested cell lines with IC50 values ranging from 13.45±1.81 to 29.01±3.21 µM.