Details

Autor(en) / Beteiligte

• Rowan, Kathryn M
• Angus, Derek C
• Bailey, Michael
• Barnato, Amber E
• Bellomo, Rinaldo
• Canter, Ruth R
• Coats, Timothy J
• Delaney, Anthony
• Gimbel, Elizabeth
• Grieve, Richard D
• Harrison, David A
• Higgins, Alisa M
• Howe, Belinda
• Huang, David T
• Kellum, John A
• Mouncey, Paul R
• Music, Edvin
• Peake, Sandra L
• Pike, Francis
• Reade, Michael C
• Sadique, M Zia
• Singer, Mervyn
• Yealy, Donald M

Titel

Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis

Ist Teil von

• The New England journal of medicine, 2017-06, Vol.376 (23), p.2223-2234

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• This study presents a patient-level meta-analysis of three recent trials of early, goal-directed therapy for septic shock. Results showed that EGDT did not improve outcomes and increased hospitalization costs across a broad range of patient and hospital characteristics. In 2001, Rivers and colleagues reported on a 263-patient, single-center, randomized, controlled trial of early, goal-directed therapy (EGDT) versus usual care in patients presenting with septic shock to an urban emergency department in the United States. 1 EGDT is a 6-hour resuscitation protocol for the administration of intravenous fluids, vasopressors, inotropes, and red-cell transfusion to achieve prespecified targets for arterial blood pressure, central venous pressure, central venous oxygen saturation, and hemoglobin level. EGDT reduced hospital mortality from 46.5% to 30.5%, 1 prompting many institutions worldwide to adopt EGDT. 2 Three subsequent, government-funded, multicenter, randomized, controlled trials from the United States (Protocolized Care for . . .