Details

Autor(en) / Beteiligte

• Luis, D. A.
• Izaola, O.
• Fuente, B.
• Primo, D.
• Aller, R.

Titel

Polymorphism of neuropeptide Y gene rs16147 modifies the response to a hypocaloric diet on cardiovascular risk biomarkers and adipokines

Ist Teil von

• Journal of human nutrition and dietetics, 2017-04, Vol.30 (2), p.159-165

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2017

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• Background The main genetic variant described in NPY gene is rs16147 (G‐399A) and it is located within the promoter region upstream of the gene for neropeptide Y (NPY). We evaluate the effects of the rs16147 NPY gene polymorphism on metabolic changes secondary to weight loss after 3 months of a hypocaloric diet in adult obese patients. Methods A population of 82 obese patients was analysed in an interventional design of one arm. Before and after 3 months on a hypocaloric diet, an anthropometric evaluation, an assessment of nutritional intake and a biochemical analysis were performed. The statistical analysis was performed for combined GA and AA as a group (minor allele group) and GG as second group (major allele group) (dominant model). Results In A allele carriers, the mean (SD) decrease in weight was −2.8 (2.2) kg [decrease in non A allele carriers −2.6 (1.1) kg, P > 0.05), body mass index was −1.2 (0.6) kg m−2 [decrease in non A allele carriers −1.1 (0.8) kg m−2, P > 0.05], fat mass was −1.7 (1.4) kg [decrease in non A allele carriers −1.9 (1.3) kg, P > 0.05], waist circumference was −5.5 (3.4) cm [decrease in non A allele carriers −3.7 (4.1) cm, P = 0.006], C‐reactive protein (CRP) was −0.7 (0.6) mg dL−1 [decrease in non A allele carriers −0.1 (0.3) mg dL−1, P = 0.02], insulin was −1.5 (0.4) mUI L−1 [decrease in non A allele carriers −0.8 (2.0) mUI L−1, P = 0.001] and homeostasis model assessment‐insulin resistance (HOMA‐IR) was −0.4 (0.5) [decrease in non A allele carriers −0.2 (0.1), P = 0.005]. interleukin (IL)‐6 changes were significant in A allele carriers [−0.7 (0.2) pg mL−1] versus non A allele carriers [−0.1 (0.3) pg mL−1] (P = 0.01). Conclusions We found that the rs164147 genotype affected the reduction of waist circumference, HOMA‐IR, insulin, CRP and IL‐6 levels in response to weight loss diet in obese subjects.