Journal of natural products (Washington, D.C.), 2003-04, Vol.66 (4), p.551-553
2003
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Details
- Autor(en) / Beteiligte
- Titel
- Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Cytosporic Acid, a Fungal Metabolite Produced by a Cytospora sp
- Ist Teil von
- Journal of natural products (Washington, D.C.), 2003-04, Vol.66 (4), p.551-553
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 2003
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition has the potential to lead to an anti-retroviral therapy that has advantages over existing therapies. Cytosporic acid (1) is a polyketide-derived novel natural product that was isolated from a fermentation broth of the filamentous fungus Cytospora sp. collected from Puerto Rico. It inhibited strand transfer reaction of HIV-1 integrase with an IC50 of 20 μM. The isolation, structure elucidation, relative stereochemistry, and activity of 1 are described.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0163-3864eISSN: 1520-6025DOI: 10.1021/np020533gTitel-ID: cdi_proquest_miscellaneous_18774295
- Format
- –
- Schlagworte
- Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents, Applied microbiology, Biological and medical sciences, Electron Spin Resonance Spectroscopy, Fermentation, Fundamental and applied biological sciences. Psychology, Fungi - chemistry, General aspects, HIV Integrase Inhibitors - chemistry, HIV Integrase Inhibitors - isolation & purification, HIV Integrase Inhibitors - pharmacology, HIV-1 - enzymology, Inhibitory Concentration 50, Microbiology, Molecular Structure, Puerto Rico, Stereoisomerism, Tetrahydronaphthalenes - chemistry, Tetrahydronaphthalenes - isolation & purification, Tetrahydronaphthalenes - pharmacology