Details

Autor(en) / Beteiligte

• Doorenweerd, Nathalie
• Hooijmans, Melissa
• Schubert, Stephanie A
• Webb, Andrew G
• Straathof, Chiara S M
• van Zwet, Erik W
• van Buchem, Mark A
• Verschuuren, Jan J G M
• Hendriksen, Jos G M
• Niks, Erik H
• Kan, Hermien E

Titel

Proton Magnetic Resonance Spectroscopy Indicates Preserved Cerebral Biochemical Composition in Duchenne Muscular Dystrophy Patients

Ist Teil von

• Journal of neuromuscular diseases, 2017, Vol.4 (1), p.53-58

Ort / Verlag

Netherlands: IOS Press BV

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin. DMD is associated with specific learning and behavioural disabilities. In the brain, dystrophin is associated with GABAA receptors and aquaporin-4 in neurons and astrocytes, respectively, but little is known about its function. In this study we aimed to compare the biochemical composition between patients and healthy controls in brain regions that are naturally rich in dystrophin using magnetic resonance spectroscopy. Given previous conflicting results obtained at clinical field strengths, we obtained data using a 7 Tesla system with associated higher signal-to-noise ratio and spectral resolution. Results indicated unchanged biochemical composition in all regions investigated, and increased variance in glutamate in the frontal cortex.