Details

Autor(en) / Beteiligte

• Arunorat, Jirapat
• Charoenvisal, Nataya
• Woonwong, Yonlayong
• Kedkovid, Roongtham
• Jittimanee, Supattra
• Sitthicharoenchai, Panchan
• Kesdangsakonwut, Sawang
• Poolperm, Pariwat
• Thanawongnuwech, Roongroje

Titel

Protection of human influenza vaccines against a reassortant swine influenza virus of pandemic H1N1 origin using a pig model

Ist Teil von

• Research in veterinary science, 2017-10, Vol.114, p.6-11

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Since the pandemic H1N1 emergence in 2009 (pdmH1N1), many reassortant pdmH1N1 viruses emerged and found circulating in the pig population worldwide. Currently, commercial human subunit vaccines are used commonly to prevent the influenza symptom based on the WHO recommendation. In case of current reassortant swine influenza viruses transmitting from pigs to humans, the efficacy of current human influenza vaccines is of interest. In this study, influenza A negative pigs were vaccinated with selected commercial human subunit vaccines and challenged with rH3N2. All sera were tested with both HI and SN assays using four representative viruses from the surveillance data in 2012 (enH1N1, pdmH1N1, rH1N2 and rH3N2). The results showed no significant differences in clinical signs and macroscopic and microscopic findings among groups. However, all pig sera from vaccinated groups had protective HI titers to the enH1N1, pdmH1N1 and rH1N2 at 21DPV onward and had protective SN titers only to pdmH1N1and rH1N2 at 21DPV onward. SN test results appeared more specific than those of HI tests. All tested sera had no cross-reactivity against the rH3N2. Both studied human subunit vaccines failed to protect and to stop viral shedding with no evidence of serological reaction against rH3N2. SIV surveillance is essential for monitoring a novel SIV emergence potentially for zoonosis. •SIV zoonotic transmission of a novel reassortant virus is possible.•A pig model for human influenza vaccine efficacy test has been established.•SN test is more specific than HI test in term of serological cross reaction among strains.•Protection of human influenza vaccines against a reassortant H3N2 SIV was failed due to the genetic incompatibility.