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Structural Disease Progression in Axial Spondyloarthritis: Still a Cause for Concern?
Ist Teil von
Current rheumatology reports, 2017-03, Vol.19 (3), p.14-14, Article 14
Ort / Verlag
New York: Springer US
Erscheinungsjahr
2017
Link zum Volltext
Quelle
SpringerLink
Beschreibungen/Notizen
Purpose of the Review
Progressive ankylosis is a feared consequence of long-standing axial spondyloarthritis. We aim to critically review current insights into the effect of therapy, the molecular pathways involved in this process, and to present a model explaining the sequence of events.
Recent Findings
Long-term follow-up data suggest that successful control of inflammation may slow down radiographic progression of disease in axial spondyloarthritis. Structural effects of new therapies such as interleukin-17 targeting need to be further studied. Bone loss and architectural changes could act as driver for the tissue remodeling process trying to maintain spinal stability in the presence of inflammation.
Summary
Despite some progress, the nature and mechanisms of new bone formation in axial spondyloarthritis still remain incompletely understood. However, long-term control of inflammation appears critical to avoid progressive disability due to structural damage.