Details

Autor(en) / Beteiligte

• Wang, Yaxin
• Wang, Junhua
• Li, Guo-Xing
• He, Gang
• Chen, Gong

Titel

Halogen-Bond-Promoted Photoactivation of Perfluoroalkyl Iodides: A Photochemical Protocol for Perfluoroalkylation Reactions

Ist Teil von

• Organic letters, 2017-03, Vol.19 (6), p.1442-1445

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A new protocol for photochemical perfluoroalkylation reactions using perfluoroalkyl iodide, amine additive, and THF solvent is reported. This protocol does not require a photoredox catalyst and proceeds at ambient temperature with irradiation from a compact fluorescent lamp, low-intensity UV lamp, or sunlight. This protocol can be applied to the synthesis of perfluoroalkyl-substituted phenanthridines as well as effect the iodo-perfluoroalkylation of alkenes/alkynes and the C–H perfluoroalkylation of electron-rich arenes and heteroarenes. This C–H perfluoroalkylation reaction offers a unique method for site-selective labeling of oligopeptides at the tryptophan residue.