Details

Autor(en) / Beteiligte

• Ni, Hao, MD
• Zhang, Xue-ping, MD
• Wang, Xiao-tong, MD
• Xia, Qiu-yuan, MD, PhD
• Lv, Jing-huan, MD
• Wang, Xuan, MD
• Shi, Shan-shan, MD
• Li, Rui, MD
• Zhou, Xiao-jun, MD, PhD
• Rao, Qiu, MD, PhD

Titel

Extended Immunologic and Genetic Lineage of Mammary Analogue Secretory Carcinoma of Salivary Glands

Ist Teil von

• Human pathology, 2016-12, Vol.58, p.97-104

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognized tumor entity. To explore a more practical and convenient immunohistochemical approach to distinguish MASC from other tumors arising from salivary glands as well as to expand the immunologic and genetic lineage of MASC, we examined 17 MASC using clinicopathologic, immunohistochemical and molecular analysis. 18 cases of acinic cell carcinoma (AciCC), 18 cases of adenoid cystic carcinoma (ACC), 22 cases of mucoepidermoid carcinoma (MEC), and 14 cases of basal cell adenocarcinoma (BCA) were brought in for comparison. 17 MASC not only shared similar architectures with intraluminal or intracellular secretion but also low-grade vesicular nuclei. In addition, they were all immunoreactive for S-100 and SOX-10, while only 3 of 17 demonstrated reactivity for GATA-3, P63, and 4 of 17 were focally positive for CD117. ETV6 translocation was detected in 10 cases by fluorescence in situ hybridization (FISH), whereas intact ETV6 was noted in 2 cases. Our data proposed a combined immunohistochemical panel to distinguish MASC from other tumors arising from salivary glands and expanded the immunologic and genetic lineage of MASC.