Details

Autor(en) / Beteiligte

• McLaughlin, Sarah
• Ahumada, Manuel
• Franco, Walfre
• Mah, Thien-Fah
• Seymour, Richard
• Suuronen, Erik J
• Alarcon, Emilio I

Titel

Sprayable peptide-modified silver nanoparticles as a barrier against bacterial colonization

Ist Teil von

• Nanoscale, 2016-11, Vol.8 (46), p.19200-19203

Ort / Verlag

England

Erscheinungsjahr

2016

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Sprayable formulations of AgNPs were prepared by exchanging citrate capping agents with LL37-SH peptides. The AgNP@LL37 material was then combined with type I collagen to form a stable film once sprayed. The AgNP@LL37 spray prevented Pseudomonas aeruginosa (P. aeruginosa) proliferation and eradicated a P. aeruginosa biofilm, while being non-toxic for human skin fibroblasts embedded within 3D artificial skin constructs. Finally, no silver infiltration was observed after spraying on a full-thickness skin wound in a mouse model.