Details

Autor(en) / Beteiligte

• Maiz, Nerea
• Wright, David
• Ferreira, Ana Fatima A.
• Syngelaki, Argyro
• Nicolaides, Kypros H.

Titel

A Mixture Model of Ductus Venosus Pulsatility Index in Screening for Aneuploidies at 11–13 Weeks’ Gestation

Ist Teil von

• Fetal diagnosis and therapy, 2012-06, Vol.31 (4), p.221-229

Ort / Verlag

Basel, Switzerland: Karger

Erscheinungsjahr

2012

Quelle

MEDLINE

Beschreibungen/Notizen

• Objective: To assess the value of ductus venosus pulsatility index for veins (DV PIV) in screening for aneuploidies at 11–13 weeks’ gestation. Methods: Fetal DV PIV was measured in singleton pregnancies undergoing first-trimester screening for aneuploidies. In euploid (n = 44,756) and aneuploid (202 cases of trisomy 21, 72 cases of trisomy 18 and 30 cases of trisomy 13) fetuses, DV PIV was best described by a mixture model of distributions. Performance of screening for aneuploidies by DV PIV alone and in combination with fetal nuchal translucency (NT) thickness and serum free β-hCG and PAPP-A was estimated. Results: In euploid pregnancies there was a bimodal distribution of DV PIV with a dominant crown-rump length (CRL)-dependent part, accounting for around 97% of cases in Caucasians and around 93% in Afro-Caribbeans, and a smaller CRL-independent distribution. In aneuploidies the dominant part was the CRL-independent distribution, which accounted for around 85% cases of trisomies 21 and 18 and 70% of cases of trisomy 13. In screening for trisomy 21 by maternal age, NT and biochemistry at a risk cutoff of 1 in 100, the detection rate was 89.7% and false positive rate was 2.74%; with addition of DV PIV, the values were 93.5 and 1.63%, respectively. Conclusions: Measurement of DV PIV improves the performance of first-trimester combined test for aneuploidies.