Details

Autor(en) / Beteiligte

• Svendsen, Frederik Holm
• Rasmussen, Peter Kristian
• Coupland, Sarah E
• Esmaeli, Bita
• Finger, Paul T
• Graue, Gerardo F
• Grossniklaus, Hans E
• Honavar, Santosh G., MD
• Khong, Jwu Jin
• McKelvie, Penelope A
• Mulay, Kaustubh
• Ralfkiaer, Elisabeth
• Sjö, Lene Dissing
• Vemuganti, Geeta K
• Thuro, Bradley A
• Curtin, Jeremy
• Heegaard, Steffen

Titel

Lymphoma of the Eyelid – An International Multicenter Retrospective Study

Ist Teil von

• American journal of ophthalmology, 2017-05, Vol.177, p.58-68

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Purpose To document subtype-specific clinical features of lymphoma of the eyelid, and their effect on patient outcome. Design Retrospective observational case series. Methods Patient data were collected from 7 international eye cancer centers from January 1st 1980 through December 31st 2015. The cases included primary and secondary lymphomas affecting the eyelid. Overall survival, disease-specific survival (DSS), and progression-free survival were the primary end points. Results Eighty-six patients were included. Mean age was 63 years and 47 (55%) were male. Non-Hodgkin B-cell lymphomas constituted 83% (n=71) and T-cell lymphomas constituted 17% (n=15). The most common subtypes were extranodal marginal-zone lymphoma (EMZL) (37% [n=32]), follicular lymphoma (FL) (23% [n=20]), diffuse large B-cell lymphoma (DLBCL) (10% [n=9]), mantle cell lymphoma (MCL) (8% [n=7]) and mycosis fungoides (MF) (9% [n=8]). EMZL had a female predilection (69% [22 of 32]), whereas MCL (71% [5 of 7]) and MF (88% [7 of 8]) had a male predominance. MCL (57% [4 of 7]), DLBCL (56% [5 of 9]) and MF (88% [7 of 8]) were frequently secondary lymphomas. Localized EMZL and FL were mostly treated with external beam radiation therapy, whereas DLBCL, MCL and high Ann Arbor stage EMZL and FL were frequently treated with chemotherapy. DLBCL and MCL had a poor prognosis (5-year DSS, 21% and 50%, respectively), whereas EMZL, FL and MF had a good prognosis (5-year DSS, 88%, 88% and 86%, respectively). Conclusions Lymphoma of the eyelid consists mainly of the lymphoma subtypes: EMZL, FL, DLBCL, MCL and MF. High-grade DLBCL and MCL as well as MF are frequently secondary eyelid lymphomas. The main predictor of outcome was the histological subtype: EMZL, FL and MF had a significantly better prognosis than MCL and DLBCL.