Pharmaceutical research, 2017-02, Vol.34 (2), p.290-300
2017
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Details
- Autor(en) / Beteiligte
- Titel
- SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study
- Ist Teil von
- Pharmaceutical research, 2017-02, Vol.34 (2), p.290-300
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Purpose To compare in vivo the total and regional pulmonary deposition of aerosol particles generated by a new system combining a vibrating-mesh nebulizer with a specific valved holding chamber and constant-output jet nebulizer connected to a corrugated tube. Methods Cross-over study comparing aerosol delivery to the lungs using two nebulizers in 6 healthy male subjects: a vibrating-mesh nebulizer combined with a valved holding chamber (Aerogen Ultra®, Aerogen Ltd., Galway, Ireland) and a jet nebulizer connected to a corrugated tube (Opti-Mist Plus Nebulizer®, ConvaTec, Bridgewater, NJ). Nebulizers were filled with diethylenetriaminepentaacetic acid labelled with technetium-99 m ( 99m Tc-DTPA, 2 mCi/4 mL). Pulmonary deposition of 99m Tc-DTPA was measured by single-photon emission computed tomography combined with a low dose CT-scan (SPECT-CT). Results Pulmonary aerosol deposition from SPECT-CT analysis was six times increased with the vibrating-mesh nebulizer as compared to the jet nebulizer (34.1 ± 6.0% versus 5.2 ± 1.1%, p < 0.001). However, aerosol penetration expressed as the three-dimensional normalized ratio of the outer and the inner regions of the lungs was similar between both nebulizers. Conclusions This study demonstrated the high superiority of the new system combining a vibrating-mesh nebulizer with a valved holding chamber to deliver nebulized particles into the lungs as comparted to a constant-output jet nebulizer with a corrugated tube.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0724-8741eISSN: 1573-904XDOI: 10.1007/s11095-016-2061-7Titel-ID: cdi_proquest_miscellaneous_1868308273
- Format
- –
- Schlagworte
- Administration, Inhalation, Adult, Aerosols, Aerosols - administration & dosage, Aerosols - chemistry, Aerosols - metabolism, Biochemistry, Biomedical and Life Sciences, Biomedical Engineering and Bioengineering, Biomedicine, Comparative analysis, Cross-Over Studies, CT imaging, Drug delivery systems, Drug Delivery Systems - methods, Equipment Design - methods, Healthy Volunteers, Humans, Inhalation Spacers, Lung - metabolism, Lungs, Male, Medical equipment, Medical Law, Nebulizers and Vaporizers, Particle Size, Pharmacology/Toxicology, Pharmacy, Prostheses and Implants, Research Paper, Respiratory therapy, SPECT imaging, Technetium - chemistry, Technetium - metabolism, Technetium Tc 99m Pentetate - chemistry, Technetium Tc 99m Pentetate - metabolism, Tomography, Emission-Computed, Single-Photon - methods, Tomography, X-Ray Computed - methods, Valves