Details

Autor(en) / Beteiligte

• Nuño‐Lámbarri, Natalia
• Barbero‐Becerra, Varenka J
• Uribe, Misael
• Chávez‐Tapia, Norberto C

Titel

Elevated cholesterol levels have a poor prognosis in a cholestasis scenario

Ist Teil von

• Journal of biochemical and molecular toxicology, 2017-01, Vol.31 (1), p.1-6

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Wiley Blackwell Single Titles

Beschreibungen/Notizen

• Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.