Journal of biochemical and molecular toxicology, 2017-01, Vol.31 (1), p.1-6
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Elevated cholesterol levels have a poor prognosis in a cholestasis scenario
- Ist Teil von
- Journal of biochemical and molecular toxicology, 2017-01, Vol.31 (1), p.1-6
- Ort / Verlag
- United States: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2017
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Cholestasis results from defective bile flow through the biliary ducts leading to the accumulation of bile acids (BAs) in hepatocytes and serum. It has been seen that cholestasis is associated with hypercholesterolemia, which is a prerequisite for gallstone formation and primary biliary cirrhosis, being some of the most common gastrointestinal disorders in Western societies. Cytotoxic BAs induce proinflammatory mediators, oxidative stress, and apoptosis in hepatocytes, whereas cytoprotective BAs prevent them; they can also modify the plasmatic membrane structure of cells or mitochondrial outer membrane properties as well as the distribution of cholesterol, altering various proteins involved in BAs homeostasis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1095-6670eISSN: 1099-0461DOI: 10.1002/jbt.21831Titel-ID: cdi_proquest_miscellaneous_1868303043
- Format
- –
- Schlagworte
- Apoptosis, Bile, bile acids, Bile Acids and Salts - blood, Cell Membrane - metabolism, Cell Membrane - pathology, cholestasis, Cholestasis - blood, Cholestasis - diagnosis, Cholestasis - etiology, Cholestasis - pathology, cholesterol, Cholesterol - blood, Gallbladder diseases, Hepatocytes - metabolism, Hepatocytes - pathology, Humans, Hypercholesterolemia - blood, Hypercholesterolemia - complications, Hypercholesterolemia - diagnosis, Hypercholesterolemia - pathology, Inflammation Mediators - blood, Mitochondria, Liver - metabolism, Mitochondria, Liver - pathology, Mitochondrial Membranes - metabolism, Mitochondrial Membranes - pathology, Oxidative Stress, Prognosis