Experimental dermatology, 2017-10, Vol.26 (10), p.958-960
2017
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- Autor(en) / Beteiligte
- Titel
- Polyphenol‐rich apple extract inhibits dexamethasone‐induced sebaceous lipids production by regulating SREBP1 expression
- Ist Teil von
- Experimental dermatology, 2017-10, Vol.26 (10), p.958-960
- Ort / Verlag
- Denmark: Wiley Subscription Services, Inc
- Erscheinungsjahr
- 2017
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (APP) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element‐binding protein 1 (SREBP 1) and its target enzymes, acetyl‐CoA carboxylase (ACC) and fatty acid synthase (FAS), in the sebocytes. However, APP inhibited Dex‐induced lipid production and expression of SREBP‐1, ACC and FAS. APP also inhibited the increase in the expression and activation of glucocorticoid receptor in the sebocytes. Taken together, these results suggest that APP may be useful to regulate sebum production and may alleviate sebum‐involved skin disease, such as acne vulgaris.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0906-6705eISSN: 1600-0625DOI: 10.1111/exd.13319Titel-ID: cdi_proquest_miscellaneous_1867984463
- Format
- –
- Schlagworte
- Acetyl-CoA carboxylase, Acetyl-CoA Carboxylase - genetics, Acetyl-CoA Carboxylase - metabolism, Acne, acne vulgaris, Cells, Cultured, Chlorogenic Acid - pharmacology, Dexamethasone, Dexamethasone - pharmacology, Excretion, Fatty Acid Synthase, Type I - genetics, Fatty Acid Synthase, Type I - metabolism, Fatty-acid synthase, Flavonoids - pharmacology, Gene Expression - drug effects, Glands, Glucocorticoids, Glucocorticoids - pharmacology, Humans, Lipids, Lipids - biosynthesis, Lipogenesis - drug effects, Plant Extracts - pharmacology, Polyphenols, Polyphenol‐rich apple extract, Primary Cell Culture, Sebaceous Glands - cytology, Sebaceous Glands - drug effects, Sebaceous Glands - metabolism, sebocytes, sebum, Skin diseases, Sterol Regulatory Element Binding Protein 1 - genetics, Sterol Regulatory Element Binding Protein 1 - metabolism, Sterol regulatory element-binding protein, Sterol response element-binding protein, sterol response element‐binding protein 1, Tannins - pharmacology