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Correlation between tumour characteristics, SUV measurements, metabolic tumour volume, TLG and textural features assessed with 18F-FDG PET in a large cohort of oestrogen receptor-positive breast cancer patients
Ist Teil von
European journal of nuclear medicine and molecular imaging, 2017-07, Vol.44 (7), p.1145-1154
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2017
Quelle
Alma/SFX Local Collection
Beschreibungen/Notizen
Purpose
The study was designed to evaluate 1) the relationship between PET image textural features (TFs) and SUVs, metabolic tumour volume (MTV), total lesion glycolysis (TLG) and tumour characteristics in a large prospective and homogenous cohort of oestrogen receptor-positive (ER+) breast cancer (BC) patients, and 2) the capability of those parameters to predict response to neoadjuvant chemotherapy (NAC).
Methods
171 consecutive patients with large or locally advanced ER+ BC without distant metastases underwent an
18
F-FDG PET examination before NAC. The primary tumour was delineated with an adaptive threshold segmentation method. Parameters of volume, intensity and texture (entropy, homogeneity, contrast and energy) were measured and compared with tumour characteristics determined on pre-treatment breast biopsy (Wilcoxon rank-sum test). The correlation between PET-derived parameters was determined using Spearman’s coefficient. The relationship between PET features and pathological findings was determined using the Wilcoxon rank-sum test.
Results
Spearman’s coefficients between SUV
max
and TFs were 0.43, 0.24, -0.43 and -0.15 respectively for entropy, homogeneity, energy and contrast; they were higher between MTV and TFs: 0.99, 0.86, -0.99 and -0.87. All TFs showed a significant association with the histological type (IDC vs. ILC; 0.02 <
P
< 0.03) but didn’t with immunohistochemical characteristics. SUV
max
and TLG predicted the pathological response (
P
= 0.0021 and
P
= 0.02 respectively); TFs didn’t (
P:
0.27, 0.19, 0.94, 0.19 respectively for entropy, homogeneity, energy and contrast).
Conclusions
The correlation of TFs was poor with SUV parameters and high with MTV. TFs showed a significant association with the histological type. Finally, while SUV
max
and TLG were able to predict response to NAC, TFs failed.