Details

Autor(en) / Beteiligte

• Song, You-Hyang
• Kim, Jae-Hyun
• Jeong, Hye-Won
• Choi, Ilsong
• Jeong, Daun
• Kim, Kwansoo
• Lee, Seung-Hee

Titel

A Neural Circuit for Auditory Dominance over Visual Perception

Ist Teil von

• Neuron (Cambridge, Mass.), 2017-02, Vol.93 (4), p.940-954.e6

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• When conflicts occur during integration of visual and auditory information, one modality often dominates the other, but the underlying neural circuit mechanism remains unclear. Using auditory-visual discrimination tasks for head-fixed mice, we found that audition dominates vision in a process mediated by interaction between inputs from the primary visual (VC) and auditory (AC) cortices in the posterior parietal cortex (PTLp). Co-activation of the VC and AC suppresses VC-induced PTLp responses, leaving AC-induced responses. Furthermore, parvalbumin-positive (PV+) interneurons in the PTLp mainly receive AC inputs, and muscimol inactivation of the PTLp or optogenetic inhibition of its PV+ neurons abolishes auditory dominance in the resolution of cross-modal sensory conflicts without affecting either sensory perception. Conversely, optogenetic activation of PV+ neurons in the PTLp enhances the auditory dominance. Thus, our results demonstrate that AC input-specific feedforward inhibition of VC inputs in the PTLp is responsible for the auditory dominance during cross-modal integration. •Audition dominates vision in mice perceiving audiovisual conflicts•The VC and AC send converging inputs to the PTLp•A neural circuit comprising the VC, AC, and PTLp computes auditory dominance•PV+ interneurons mediate feedforward inhibition of visual inputs in the PTLp Song et al. describe a neural circuit for the integration of cross-modal sensory conflicts. In head-fixed mice perceiving audiovisual conflicts, audition dominates vision via feedforward inhibition of visual inputs by auditory inputs as they converge in the posterior parietal cortex.