Details

Autor(en) / Beteiligte

• Shen, De-Feng
• Wu, Shan-Shan
• Wang, Rui-Rui
• Zhang, Qiang
• Ren, Zhong-Juan
• Liu, Hong
• Guo, Hua-Dong
• Gao, Guang-Gang

Titel

A Silver(I)-Estrogen Nanocluster: GSH Sensitivity and Targeting Suppression on HepG2 Cell

Ist Teil von

• Small (Weinheim an der Bergstrasse, Germany), 2016-11, Vol.12 (44), p.6153-6159

Ort / Verlag

Germany: Blackwell Publishing Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• A structure‐determined silver nanocluster of [Ag10(Eth)4(CF3COO)6(CH3OH)3]·3C­H3OH (Eth = ethisterone) (1), is firstly demonstrated by self‐assembly of silver salt and ethisterone. Due to the thiophilicity of silver(I) ions, complex 1 shows reactivity with glutathione (GSH) molecules in solution and induces the fluorescence quenching behavior. Thus, complex 1 can be used as a fluorescent sensor for GSH. In consideration of the higher level of GSH in cancerous cells, complex 1 presents significant tumor suppression reactivity toward the human hepatocellular carcinoma (HepG2) cells with IC50 value of 165 × 10−9 m. Especially, complex 1 displays 3.4‐fold higher in vitro cytotoxicity to HepG2 cells than that of the normal CCC‐HEL‐1 cells, which makes complex 1 a potential targeting suppression agent for cancerous cells. The molecular design of complex 1 not only generates a new medicine‐silver(I) cluster family, but also opens a new avenue to the targeting anticancer organosilver(I) materials. A structure‐determined silver nano­­­cluster of [Ag10(Eth)4(CF3COO)6(CH3OH)3]·3CH3OH (Eth = ethisterone) (1), demonstrated for the first time, shows reactivity with glutathione molecules in solution and induces the fluorescence quenching behavior. Complex 1 displays 3.4‐fold higher in vitro cytotoxicity to HepG2 cells than that of the normal CCC‐HEL‐1 cells, which makes 1 a potential targeting suppression agent for cancerous cells.