Details

Autor(en) / Beteiligte

• Zonta, G.
• Anania, G.
• Fabbri, B.
• Gaiardo, A.
• Gherardi, S.
• Giberti, A.
• Landini, N.
• Malagù, C.
• Scagliarini, L.
• Guidi, V.

Titel

Preventive screening of colorectal cancer with a device based on chemoresistive sensors

Ist Teil von

• Sensors and actuators. B, Chemical, 2017-01, Vol.238, p.1098-1101

Ort / Verlag

Lausanne: Elsevier B.V

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• •The paper is a feasibility proof for a colorectal cancer preventive screening with a device based on chemoresistive sensors.•Laboratory tests have been performed with different combinations of sensing materials, chosing the best combination of five sensors.•Tests have been performed on fecal samples of healthy subjects and of patients affected by colorectal cancer, showing noticeable differences.•A quadratic discriminant analysis (QDA) has been performed, with a classification error of about 5%. Colorectal cancer is one of the widely diffused tumors. Despite its high curable rate, if diagnosed in its polyp state, an efficient screening method is highly desirable for preventing and decreasing deaths. Tumor biomarkers, emitted by the peroxidation of the cell membrane, may alter the composition of feces. We developed an array of chemoresistive sensors (both metal oxides and sulfides) capable of distinguishing between real stool samples of healthy subjects and of patients with colorectal cancer at diverse degeneration stages. Preliminary clinical validation of real samples was carried out. Results have shown the selectivity of the sensor array towards tumor affected and healthy subject samples. A quadratic discriminant analysis was performed, with a classification error of about 5%.