Postępy biochemii, 2016, Vol.62 (1), p.46-51
2016
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- Autor(en) / Beteiligte
- Titel
- Microtubule severing proteins - structure and activity regulation
- Ist Teil von
- Postępy biochemii, 2016, Vol.62 (1), p.46-51
- Ort / Verlag
- Poland
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Microtubule severing proteins, katanin, spastin and fidgetin cause local destabilization of the microtubules structure. This ATP-dependent activity leads to the shortening or disassembly of the existing microtubules. The generated short microtubule fragments may serve as templates to polymerize new microtubules and in consequence, the activity of the microtubule severing proteins leads to the reorganization of the microtubular cytoskeleton. This review summarizes current knowledge concerning structural organization of the microtubule severing proteins, the molecular mechanism of their action, factors that regulate the level of the katanin and spastin within the cells and their microtubule severing activity.
- Sprache
- Polnisch
- Identifikatoren
- ISSN: 0032-5422Titel-ID: cdi_proquest_miscellaneous_1862937374
- Format
- –
- Schlagworte
- Adenosine Triphosphate - metabolism, Animals, ATPases Associated with Diverse Cellular Activities - chemistry, ATPases Associated with Diverse Cellular Activities - metabolism, Humans, Katanin - chemistry, Katanin - metabolism, Microtubule-Associated Proteins - chemistry, Microtubule-Associated Proteins - metabolism, Microtubules - metabolism, Protein Conformation, Spastin - chemistry, Spastin - metabolism