Details

Autor(en) / Beteiligte

• Xu, Hua-Jin
• Lu, Yi
• Farmer, Marcus E
• Wang, Huai-Wei
• Zhao, Dan
• Kang, Yan-Shang
• Sun, Wei-Yin
• Yu, Jin-Quan

Titel

Rh(III)-Catalyzed meta-C–H Olefination Directed by a Nitrile Template

Ist Teil von

• Journal of the American Chemical Society, 2017-02, Vol.139 (6), p.2200-2203

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• A range of Rh­(III)-catalyzed ortho-C–H functionalizations have been developed; however, extension of this reactivity to remote C–H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first example of the use of a U-shaped nitrile template to direct Rh­(III)-catalyzed remote meta-C–H activation via a postulated 12-membered macrocyclic intermediate. Because the ligands used for Rh­(III) catalysts are significantly different from those of Pd­(II) catalysts, this offers new opportunities for future development of ligand-promoted meta-C–H activation reactions.