Details

Autor(en) / Beteiligte

• Han, Zhihao
• Lv, Liwei
• Ma, Yi
• Wang, Zhaohui
• Liu, Yuxi
• Zhang, Min
• Li, Siwen
• Gu, Yueqing

Titel

Cypate‐mediated thermosensitive nanoliposome for tumor imaging and photothermal triggered drug release

Ist Teil von

• Journal of biophotonics, 2017-12, Vol.10 (12), p.1607-1616

Ort / Verlag

Weinheim: WILEY‐VCH Verlag

Erscheinungsjahr

2017

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano‐liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2.1. And the liposome achieved the functions of target‐delivery, enhanced photochemical internalized drug release, and simultaneous chemotherapy and thermal therapy, indicating that this multifunctional nano‐liposome is a promising drug delivery system for tumor diagnosis and targeting therapy. Nanoscale drug delivery systems are attracting considerable attention as an alternative strategy to overcome a lot of limitation. The multifunctional photothermal sensitive liposomes drug‐loading system was established, with cypate and DOX carried in it for multi‐mechanism diagnosis and treatment of tumor diseases. The attractive features of DOX@PTSL demonstrated here support the anticipation of its promising prospect in cancer therapy.