Bulletin of experimental biology and medicine, 2017, Vol.162 (3), p.306-309
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Effects of Deltorphin II and Its Retroenantio Analog on Cardiac Tolerance to Ischemia and Reperfusion
- Ist Teil von
- Bulletin of experimental biology and medicine, 2017, Vol.162 (3), p.306-309
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Selective agonist of δ 2 -opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and before reperfusion decreased the infarct size/area at risk ratio. Deltorphin II prevented the appearance of ischemia-provoked ventricular arrhythmias and exerted no effect on HR and BP (systolic and diastolic). The retroenantio analog of deltorphin II produced no antiarrhythmic or infarct - limiting effects, but reduced HR without affecting BP. Deltorphin II can be viewed as a promising prototype for a medicinal remedy to treat acute myocardial infarction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0007-4888eISSN: 1573-8221DOI: 10.1007/s10517-017-3601-9Titel-ID: cdi_proquest_miscellaneous_1861533788
- Format
- –
- Schlagworte
- Amino acids, Analgesics, Opioid - pharmacology, Animals, Arrhythmia, Arrhythmias, Cardiac - drug therapy, Arrhythmias, Cardiac - metabolism, Arrhythmias, Cardiac - physiopathology, Biomedical and Life Sciences, Biomedicine, Blood Pressure - drug effects, Cardiac arrhythmia, Cardiotonic Agents - pharmacology, Cell Biology, Cerebrovascular Disorders, Coronary Vessels - surgery, Deltorphin II, Endogenous opioids, General Pathology and Pathophysiology, Heart, Heart diseases, Heart Rate - drug effects, Injections, Intravenous, Internal Medicine, Ischemia, Laboratory Medicine, Male, Myocardial infarction, Myocardial Reperfusion Injury - drug therapy, Myocardial Reperfusion Injury - metabolism, Myocardial Reperfusion Injury - physiopathology, Occlusion, Oligopeptides - pharmacology, Opioid receptors, Pathology, Rats, Rats, Wistar, Receptors, Opioid, delta - agonists, Receptors, Opioid, delta - metabolism, Reperfusion, Rodents, Stereoisomerism, Ventricle