Details

Autor(en) / Beteiligte

• Vuksan, V
• Jenkins, A.L
• Brissette, C
• Choleva, L
• Jovanovski, E
• Gibbs, A.L
• Bazinet, R.P
• Au-Yeung, F
• Zurbau, A
• Ho, H.V.T
• Duvnjak, L
• Sievenpiper, J.L
• Josse, R.G
• Hanna, A

Titel

Salba-chia ( Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: A double-blind randomized controlled trial

Ist Teil von

• Nutrition, metabolism, and cardiovascular diseases, 2017-02, Vol.27 (2), p.138-146

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Background and Aim Preliminary findings indicate that consumption of Salba-chia ( Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes. Methods A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA1c : 6.5–8.0%; BMI: 25–40 kg/m2 ). Both groups followed a 6-month calorie-restricted diet; one group received 30 g/1000 kcal/day of Salba-chia, the other 36 g/1000 kcal/day of an oat bran-based control. Primary endpoint was change in body weight over 6-months. Secondary endpoints included changes in waist circumference, body composition, glycemic control, C-reactive protein, and obesity-related satiety hormones. Results At 6-months, participants on Salba-chia had lost more weight than those on control (1.9 ± 0.5 kg and 0.3 ± 0.4 kg, respectively; P  = 0.020), accompanied by a greater reduction in waist circumference (3.5 ± 0.7 cm and 1.1 ± 0.7 cm, respectively; P  = 0.027). C-reactive protein was reduced by 1.1 ± 0.5 mg/L (39 ± 17%) on Salba-chia, compared to 0.2 ± 0.4 mg/L (7 ± 20%) on control ( P  = 0.045). Plasma adiponectin on the test intervention increased by 6.5 ± 0.7%, with no change observed on control ( P  = 0.022). Conclusions The results of this study, support the beneficial role of Salba-chia seeds in promoting weight loss and improvements of obesity related risk factors, while maintaining good glycemic control. Supplementation of Salba-chia may be a useful dietary addition to conventional therapy in the management of obesity in diabetes. Registration clinicaltrials.gov identifier: NCT01403571.