Details

Autor(en) / Beteiligte

• Bi, L L
• Gao, Y
• Sun, Y J
• Kong, X R
• He, X Y
• Ma, X H
• Zhang, W H
• Xiao, L
• Shi, B Y

Titel

Research of mHLA-G and the receptor expression with kidney rejection and CMV active infection following kidney transplantation

Ist Teil von

• Zhong hua yi xue za zhi, 2017-01, Vol.97 (2), p.104-107

Ort / Verlag

China

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• To study the expression of membrane HLA-G (mHLA-G) and the receptor immunoglobulin-like transcript 2(ILT2) on lymphocyte and find their association with rejection and cytomegalovirus (CMV) infection after renal transplantation. A total of 88 cases of renal transplant recipients for the first time from February 2014 to February 2016 were studied in this work. Recipients can be divided into rejection group ( =12) and stable renal function group ( =41) according to whether rejection occurred. Recipients only infected CMV not developed rejection were included in the CMV positive group ( =24). CMV negative group ( =11) including CMV negative recipients once infected CMV.The expression of mHLA-G and ILT2 on lymphocytes were detected by flow cytometry, and the differences among different groups were analyzed. The data showed that after renal transplantation, T and B lymphocytes mHLA-G expression rate was the lowest in the rejection group (0.42%±0.35%, 0.88%±0.47%), having significant difference with renal function s