Details

Autor(en) / Beteiligte

• Xia, Changkun
• White, Andrew J. P
• Hii, King Kuok Mimi

Titel

Synthesis of Isoindolinones by Pd-Catalyzed Coupling between N‑Methoxybenzamide and Styrene Derivatives

Ist Teil von

• Journal of organic chemistry, 2016-09, Vol.81 (17), p.7931-7938

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• An atom-economical protocol for a tandem process involving Fujiwara–Moritani–aza-Wacker reactions has been developed for the Pd-catalyzed coupling between N-methoxy benzamide and styrene derivatives. The generality of the methodology was demonstrated by the synthesis of a library of 25 3-benzylidene isoindolinones in moderate to good yields. A further 40 3-benzyl derivatives were obtained by telescoping the process with a catalytic hydrogenation reaction.