Neuroscience, 2017-02, Vol.342, p.101-119
2017
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- Autor(en) / Beteiligte
- Titel
- Effects of early-life stress on cognitive function and hippocampal structure in female rodents
- Ist Teil von
- Neuroscience, 2017-02, Vol.342, p.101-119
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Effects of early stress were studied on later hippocampal structure and function. • To rescue these effects, 50% were treated with a GR blocker during puberty. • Neither early stress nor GR blockade affected behavioral performance in female rats. • Also, dentate gyrus structure, proliferation and neurogenesis did not differ. • As confirmed by literature, females may be more resilient to early-life stress.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2015.08.024Titel-ID: cdi_proquest_miscellaneous_1859496737
- Format
- –
- Schlagworte
- Animals, Animals, Newborn, Anxiety - etiology, Anxiety - pathology, Anxiety - physiopathology, Anxiety - prevention & control, Cognition - drug effects, Cognition - physiology, contextual memory, depression, Disease Models, Animal, Female, Gambling - etiology, Gambling - pathology, Gambling - physiopathology, Gambling - prevention & control, hippocampus, Hippocampus - drug effects, Hippocampus - growth & development, Hippocampus - pathology, Hormone Antagonists - pharmacology, Maternal Deprivation, Memory - drug effects, Memory - physiology, Mifepristone - pharmacology, neurogenesis, Neurogenesis - drug effects, Neurogenesis - physiology, Neurology, Neurons - drug effects, Neurons - pathology, prefrontal cortex, Random Allocation, Rats, Wistar, Receptors, Glucocorticoid - antagonists & inhibitors, Receptors, Glucocorticoid - metabolism, sex difference, Sexual Maturation, Stress, Psychological - complications, Stress, Psychological - drug therapy, Stress, Psychological - pathology, Stress, Psychological - physiopathology, Treatment Failure