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Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass
Journal of bone and mineral research, 2017-01, Vol.32 (1), p.181-187
Genant, Harry K
Engelke, Klaus
Bolognese, Michael A
Mautalen, Carlos
Brown, Jacques P
Recknor, Chris
Goemaere, Stefan
Fuerst, Thomas
Yang, Yu‐Ching
Grauer, Andreas
Libanati, Cesar
2017
Details
Autor(en) / Beteiligte
Genant, Harry K
Engelke, Klaus
Bolognese, Michael A
Mautalen, Carlos
Brown, Jacques P
Recknor, Chris
Goemaere, Stefan
Fuerst, Thomas
Yang, Yu‐Ching
Grauer, Andreas
Libanati, Cesar
Titel
Effects of Romosozumab Compared With Teriparatide on Bone Density and Mass at the Spine and Hip in Postmenopausal Women With Low Bone Mass
Ist Teil von
Journal of bone and mineral research, 2017-01, Vol.32 (1), p.181-187
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
ABSTRACT Romosozumab, a monoclonal antibody that binds sclerostin, has a dual effect on bone by increasing bone formation and reducing bone resorption, and thus has favorable effects in both aspects of bone volume regulation. In a phase 2 study, romosozumab increased areal BMD at the lumbar spine and total hip as measured by DXA compared with placebo, alendronate, and teriparatide in postmenopausal women with low bone mass. In additional analyses from this international, randomized study, we now describe the effect of romosozumab on lumbar spine and hip volumetric BMD (vBMD) and BMC at month 12 as assessed by QCT in the subset of participants receiving placebo, s.c. teriparatide (20 µg once daily), and s.c. romosozumab (210 mg once monthly). QCT measurements were performed at the lumbar spine (mean of L1 and L2 entire vertebral bodies, excluding posterior processes) and hip. One year of treatment with romosozumab significantly increased integral vBMD and BMC at the lumbar spine and total hip from baseline, and compared with placebo and teriparatide (all p < 0.05). Trabecular vertebral vBMD improved significantly and similarly from baseline (p < 0.05) with both romosozumab (18.3%) and teriparatide (20.1%), whereas cortical vertebral vBMD gains were larger with romosozumab compared with teriparatide (13.7% versus 5.7%, p < 0.0001). Trabecular hip vBMD gains were significantly larger with romosozumab than with teriparatide (10.8% versus 4.2%, p = 0.01), but were similar for cortical vBMD (1.1% versus –0.9%, p = 0.12). Cortical BMC gains were larger with romosozumab compared with teriparatide at both the spine (23.3% versus 10.9%, p < 0.0001) and hip (3.4% versus 0.0%, p = 0.03). These improvements are expected to result in strength gains and support the continued clinical investigation of romosozumab as a potential therapy to rapidly reduce fracture risk in ongoing phase 3 studies. © 2016 American Society for Bone and Mineral Research.
Sprache
Englisch
Identifikatoren
ISSN: 0884-0431
eISSN: 1523-4681
DOI: 10.1002/jbmr.2932
Titel-ID: cdi_proquest_miscellaneous_1859495643
Format
–
Schlagworte
Absorptiometry, Photon
,
Aged
,
Aged, 80 and over
,
ANABOLICS
,
Antibodies, Monoclonal - pharmacology
,
Bone Density - drug effects
,
BONE QCT
,
CLINICAL TRIALS
,
Demography
,
Female
,
Hip - anatomy & histology
,
Hip - diagnostic imaging
,
Hip - physiology
,
Humans
,
Lumbar Vertebrae - drug effects
,
Lumbar Vertebrae - physiology
,
Middle Aged
,
Organ Size - drug effects
,
OSTEOPOROSIS
,
Postmenopause - drug effects
,
Spine - anatomy & histology
,
Spine - diagnostic imaging
,
Spine - physiology
,
Teriparatide - pharmacology
,
Tomography, X-Ray Computed
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