Brain research bulletin, 2017-01, Vol.128, p.29-33
2017
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- Autor(en) / Beteiligte
- Titel
- Effect of co-administration of memantine and sertraline on the antidepressant-like activity and brain-derived neurotrophic factor (BDNF) levels in the rat brain
- Ist Teil von
- Brain research bulletin, 2017-01, Vol.128, p.29-33
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights • Sertraline combined with memantine induced a more pronounced antidepressant activity. • Sertraline combined with memantine increased BDNF levels in the brain. • In drug-resistant patients sertraline combine with memantine could be an alternative.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0361-9230eISSN: 1873-2747DOI: 10.1016/j.brainresbull.2016.11.003Titel-ID: cdi_proquest_miscellaneous_1859484987
- Format
- –
- Schlagworte
- Animals, Antidepressive Agents - administration & dosage, Brain - drug effects, Brain - metabolism, Brain-derived neurotrophic factor, Brain-Derived Neurotrophic Factor - metabolism, Depression, Depressive Disorder - drug therapy, Depressive Disorder - metabolism, Disease Models, Animal, Dose-Response Relationship, Drug, Drug Therapy, Combination, Excitatory Amino Acid Antagonists - pharmacology, Male, Memantine, Memantine - administration & dosage, Neurology, NMDA receptor, Rat brain, Rats, Wistar, Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate - metabolism, Sertraline - administration & dosage