Details

Autor(en) / Beteiligte

• Rades, Dirk
• Huttenlocher, Stefan
• Gebauer, Niklas
• Hornung, Dagmar
• Trang, Ngo Thuy
• Khoa, Mai Trong
• Schild, Steven E

Titel

Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma

Ist Teil von

• Anticancer research, 2015-06, Vol.35 (6), p.3571-3574

Ort / Verlag

Greece

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy. SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006). In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.