Details

Autor(en) / Beteiligte

• Rades, Dirk
• Huttenlocher, Stefan
• Rudat, Volker
• Hornung, Dagmar
• Blanck, Oliver
• Phuong, Pham Cam
• Khoa, Mai Trong
• Schild, Steven E
• Fischer, Dorothea

Titel

Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses

Ist Teil von

• Anticancer research, 2015-01, Vol.35 (1), p.333-336

Ort / Verlag

Greece

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer. Patients receiving 20 Gy (n=20) were compared to those receiving 16-18.5 Gy (n=10) for local control, distant brain control and overall survival. Seven other variables were also evaluated. Radiosurgery dose achieved significance on univariate (p=0.002; log-rank and Wilcoxon test) and multivariate analysis (p=0.004) of local control. Twelve-month local control rates were 94% after 20 Gy and 48% after 16-18.5 Gy. On univariate analysis of distant brain control, radiosurgery dose was not a significant factor, with 12-month rates of 73% and 60%, respectively. Regarding overall survival, radiosurgery dose was of borderline significance (p=0.059; Wilcoxon test). Twelve-month overall survival rates were 75% and 40%, respectively. On Cox regression analysis, radiosurgery dose exhibited a trend for improving survival (p=0.10). Radiosurgery with 20 Gy resulted in significantly better local control and led to a trend towards improved overall survival compared to treatment with 16-18.5 Gy.