Cancer letters, 2016-02, Vol.371 (1), p.1-11
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Perturbation of energy metabolism by fatty-acid derivative AIC-47 and imatinib in BCR-ABL-harboring leukemic cells
- Ist Teil von
- Cancer letters, 2016-02, Vol.371 (1), p.1-11
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Imatinib strongly suppresses Warburg effect through the down-regulation of PTBP1. • Fatty-acid oxidation (FAO) supports glucose-independent survival in imatinib-treated cells. • Inactivation of BCR-ABL activates compensatory FAO. • AIC-47 perturbs both glycolysis and FAO. • The inhibition of glycolysis and FAO can be effective for the CD34+ fraction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2015.11.020Titel-ID: cdi_proquest_miscellaneous_1859477709
- Format
- –
- Schlagworte
- Acids, Antigens, CD34 - metabolism, Antineoplastic Combined Chemotherapy Protocols - pharmacology, BCR-ABL, Binding sites, Cancer, Conflicts of interest, CPT1C, Dose-Response Relationship, Drug, Drug Synergism, Energy Metabolism - drug effects, Enzymes, Experiments, Fatty Acids - pharmacology, Fatty-acid oxidation, Fusion Proteins, bcr-abl - genetics, Fusion Proteins, bcr-abl - metabolism, Glycolysis - drug effects, Hematology, Oncology and Palliative Medicine, Heterocyclic Compounds, 1-Ring - pharmacology, Heterogeneous-Nuclear Ribonucleoproteins - genetics, Heterogeneous-Nuclear Ribonucleoproteins - metabolism, Humans, Imatinib, Imatinib Mesylate - pharmacology, Immunoglobulins, K562 Cells, Ketones - pharmacology, Kinases, Leukemia, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics, Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism, Metabolism, MicroRNAs - genetics, MicroRNAs - metabolism, Neoplastic Stem Cells - drug effects, Neoplastic Stem Cells - metabolism, Oxidation-Reduction, Polypyrimidine Tract-Binding Protein - genetics, Polypyrimidine Tract-Binding Protein - metabolism, Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics, Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism, Protein Kinase Inhibitors - pharmacology, Proteins, Pyruvate Kinase - genetics, Pyruvate Kinase - metabolism, RNA Interference, Stem cells, Transfection, Warburg effect